Imbalance of the adrenal gland stress hormones cortisol and (nor)epinephrine have been correlated with stress-related mental conditions such as depression and post trauma stress disorder (PTSD). We developed an approach to directly trigger hormone release from the adrenal glands via the activation of heat sensitive ion channels mediated by the magneto-thermal approach. Adrenal hormones influence and are influenced by multiple physiological systems including communication with the brain. We are broadening the novel developed magnetothermal approach to explore similar modalities of the adrenal gland and the stress hormones role in neurological disorders.